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Chapter 3_2011(2) - Chapter 3 Mechanisms of Toxicity Click...

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Click to edit Master subtitle style 4/10/11 Chapter 3 Mechanisms of Toxicity
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4/10/11 Overview of how toxicity occurs Toxican t Alteration of local environment Cellular dysfunction/ injury Exposure to organism Interacti on with target Toxicity Dysrepair
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4/10/11 Overview of how toxicity occurs Toxican t Alteration of local environment Cellular dysfunction/ injury Exposure to organism Interacti on with target Toxicity Dysrepair Contaminant seeps into organism’s home environment
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4/10/11 Overview of how toxicity occurs Toxican t Alteration of local environment Cellular dysfunction/ injury Exposure to organism Interacti on with target Toxicity Dysrepair Contaminant gets into “inner environment” (A & D of ADME)
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4/10/11 Overview of how toxicity occurs Toxican t Alteration of local environment Cellular dysfunction/ injury Exposure to organism Interacti on with target Toxicity Dysrepair Contaminant starts bonding to target molecules within a target tissue compartment
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4/10/11 Overview of how toxicity occurs Toxican t Alteration of local environment Cellular dysfunction/ injury Exposure to organism Interacti on with target Toxicity Dysrepair -this alone may be a source of injury able to produce toxicity
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4/10/11 Overview of how toxicity occurs Toxican t Alteration of local environment Cellular dysfunction/ injury Exposure to organism Interacti on with target Toxicity Dysrepair But in some cases, the interaction with the target molecule simply sets up a cascade effect
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4/10/11 Overview of how toxicity occurs Toxican t Alteration of local environment Cellular dysfunction/ injury Exposure to organism Interacti on with target Toxicity Dysrepair -which then causes tissue injury
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4/10/11 Overview of how toxicity occurs Toxican t Alteration of local environment Cellular dysfunction/ injury Exposure to organism Interacti on with target Toxicity Dysrepair And sometimes the target molecule is skipped altogether.
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4/10/11 Overview of how toxicity occurs Toxican t Alteration of local environment Cellular dysfunction/ injury Exposure to organism Interacti on with target Toxicity Dysrepair -which then causes tissue injury by alteration of tissue homeostasis
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4/10/11 Overview of how toxicity occurs Toxican t Alteration of local environment Cellular dysfunction/ injury Exposure to organism Interacti on with target Toxicity Dysrepair Cell dysfunction is when normal activity has stopped; this may be reversible, and may not mean the death of any tissue. This could just be slowed function.
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4/10/11 Overview of how toxicity occurs Toxican t Alteration of local environment Cellular dysfunction/ injury Exposure to organism Interacti on with target Toxicity Dysrepair When the target molecule/ cell/ tissue cannot effectively repair damage occurs. Which can be observed as toxicity
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