Cell_Death_1A_2010

Cell_Death_1A_2010 - Development of the Nervous System...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Development of the Nervous System - Survival and Death at the Cellular Level MCDB 1A November 9, 2010
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
A Neurocentric Perspective Of Development Fertilization --> Blastula --> Gastrula --> Neurula •Neuroblast Proliferation •Neuroblast Migration •Axon Outgrowth/Navigation •Programmed Cell Death •Synaptic Rearrangements •Active Maintenance of Neuronal Cells
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Axon Outgrowth, Navigation and Synapse Formation Target of Innervation ? Target of Innervation Is there a relationship between the pool of innervating neurons and the target?
Background image of page 4
Outline 1. The early days – the “Recruitment Model” of Shorey and Detwiler 2. Viktor Hamburger – Naturally Occurring Cell Death 3. Rita Levi-Montalcini and Stanley Cohen – Discovery of NGF and Related Factors 4. Quick Look at Molecular Mechanisms of Neuronal Survival
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
1. The early days – the “Recruitment” Model
Background image of page 6
1909 - M.L. Shorey Question: Is there a relationship between targets of innervation and the pool of innervating neurons? Expt: Remove the limb bud from one side of a 3 day chick embryo and see what happens;
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
1909 - M.L. Shorey Question: Is there a relationship between targets of innervation and the pool of innervating neurons? Expt: Removes limb bud from one side of a chick embryo and see what happens; Result: Many fewer neurons in the region of the spinal cord that would ordinarily innervate the “missing” limb; BUT, the expt was not done very quantitatively very tough for technical reasons
Background image of page 8
1920 - Detwiler does both limb ablation and limb addition (aka, “supernumerary limbs”) Control Ablation Control
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 33

Cell_Death_1A_2010 - Development of the Nervous System...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online