Orgo Unit 6.1 Discussion

Orgo Unit 6.1 Discussion -...

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Topic # 1: List the three requirements for a substitution reaction to proceed via the SN1 mechanism. In order for us to assess which three requirements are needed for a substitution reaction to proceed via the SN1 mechanism, let’s first briefly review what the SN1 reaction entails. According to the textbook, an SN1 reaction means that the reaction proceeds via a substitution reaction, in which there is a nucleophilic (recall: a molecule with a negative charge or has high electron density) attack on an electrophile, and it is unimolecular. In the SN1 reaction, the leaving group departs from the molecule. A carbocation forms, which is then attacked by a nucleophile. Given that overview of the SN1 reaction, we can begin to consider what is needed for such a reaction to proceed. As we see above, the first step of the reaction is that a leaving group leaves the molecule and forms a carbocation intermediate. Naturally, an important requirement to consider is having an excellent leaving group. After all, in order for the SN1 to begin, the leaving
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This note was uploaded on 04/10/2011 for the course AAS 410.302.81 taught by Professor Thompson during the Spring '11 term at Johns Hopkins.

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