Orgo Unit 6.2 Discussion

Orgo Unit 6.2 Discussion - ion As the base attacks the...

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Topic # 2: What structural and reactivity factors are necessary for an E2 reaction  to occur? As I had done in my previous topic response, I will first provide an overview of what an E2 reaction entails before discussing the relevant reactivity factors needed for an E2 reaction to occur. As with an SN2 reaction, the rate of an E2 reaction is dependent on the concentration of two compounds. The reaction proceeds such that a nucleophile attacks and a leaving group departs from the substrate simultaneously. As indicated in the textbook, one of the important activities that is occurring in the E2 reaction is the removal of a proton by the base. Thus, a strong base will be needed in order for an E2 reaction to occur (e.g., hydroxide
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Unformatted text preview: ion). As the base attacks the substrate, the leaving group will also depart from the molecule. Therefore, a good leaving group will also favor an E2 reaction. There is some give and take between the strength of the base and the quality of the leaving group. If we have a very good leaving group, a weaker base can be used. If we have a very strong base, we can have a weaker leaving group. Lastly, we see that elimination reactions result in the formation of a double bond and the departure of the leaving group. In order for the reaction to occur, we will also need the proton to be beta to the leaving group in order for the double bond to properly be formed....
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