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Unformatted text preview: negative charge on halogens) make good leaving groups. Additionally, molecules with resonance stabilized negative charges also make good leaving groups. Additionally, we want a molecule that will form a stable carbocation once the leaving group departs. Accordingly, substrates that result in more highly substituted carbocations will favor E1 reactions. From what we already know about carbon atoms, they are electron donors, which will stable the carbocation. This is because alkyl groups donate electron density to stabilize the carbocation molecule. The last factor we consider is that we need a polar solvent for E1 reactions to occur . This will stabilize the carbocation intermediate. And as previously mentioned, the hydrogen that will be removed from the molecule should be beta to the leaving group for the alkene to properly form....
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This note was uploaded on 04/10/2011 for the course AAS 410.302.81 taught by Professor Thompson during the Spring '11 term at Johns Hopkins.
- Spring '11