Bio Unit 3.1 Discussion

Bio Unit 3.1 Discussion - 1.) Please discuss the structure...

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1.) Please discuss the structure and biological function of lysosomes in cells and the consequences caused by their malfunctioning. According to the Life: The Science of Biology textbook, Lysosomes are responsible for the intracellular digestion of macromolecules. They contain soluble hydrolytic enzymes in compartments enclosed by membranes. The enzymes are all acid hydrolases, which means that they work best in acidic environments. More specifically, proteolytic cleavage must occur and these enzymes need to be in acidic environments to become activated. Because of this, the environment inside of lysosomes has a pH or roughly 4.5-5.0 (Weissman, 1965). Overall, the various enzymes include proteases, nucleases, glycosidases, lipases, phospholipases, phosphatases, and sulfatases (Weissman, 1965); all of these components sound very familiar, right? They are all enzymes that have some relation to the components of the various macromolecules we learned from the last unit of the course. One special feature of the lysosome is its thick membrane, which prevents these enzymes from leaking out and attacking other organelles in the cell. Of course,
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This note was uploaded on 04/10/2011 for the course AAS 410.303.81 taught by Professor Pan during the Spring '11 term at Johns Hopkins.

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Bio Unit 3.1 Discussion - 1.) Please discuss the structure...

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