BMB 440 Exam II F'09

BMB 440 Exam II F'09 - EXAM2 5 BMB 440 Introductory...

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Unformatted text preview: EXAM2 5 BMB 440 Introductory Immunology Fall 2009 I. What are the characteristics of the “immunoglobulin fold” of members of the immunoglobulin superfamily. Why is this structure thought to be so important? List three members of 's fqmil other that: immunoglobulins, 'TCRs: and MHC 10 pts) The tmyggl‘ohflm 0H ts conStstEd' 0‘: a; [/0 ammo acid sew/2" ,2 Mfipamflc/ 3'?ch 6 sheets aha/cannecita’ by disulfidc boat/4m! are szpa/afzd 1254.2 cgsh'me about 60 Ammo auto/5 apAr-L 7h shudure Us MSH {o be so 1.4%, [importan because [PL 'mtcradcs M'H‘h ’{lbodiesI I3 mo t 15 the important In the SIISM‘ Jcransaluc 1m {pail my. 3 members a; /a_: this fiwhlfl Ma Pa}! —I3 file/{Lbytofi’ Vii/3M5, and II. List the genetic mechanisms which contribute to the diversity of immunoglobulins? (15 pts) , ‘/P— nucleottdc addition \/N- nudeox' tie addlhofl t/DNA racoMb'tnaf'ton / 3L Light chain narmy’gcmtm; ‘/‘L) C .a :0. II 0 J L/ Dfi- Hawks I‘m“: (alum-3 Wtfl‘nf 111. What are the differences in the types of antigens recognized by antibodies and T cell receptors? (15 pts) Mlabolles m der'wcd 43m 13- ceNs and race nlzes non- .nalured proteins, TM WW?“ that are moaned b5 MM: is; are WM: and usuale "MM Wts'dfi 0:? fie antigenic shudure. WI}: [458! is (Wang ans-[sf hadch m b )41“ may; at .3", gp'mfgs are, Mdrophillc. chsa epxiafes m n alum'l’ml saunas; M the “£33m. Tee“ renews rcc03n'e55 Nisan: «But are firsh/de/nafured and warmed bj MHC lecs. These cp'rkoyes..ar «aux {it Mel/ml frafa'n Quaint/1155 Hut are bmkw down. Because Most 05%; splays are 'mlunal aims, it means 4;", epiloycs on Md 5197mm mm" are «gm/{7 a/flzh'c. IV. Explain why a \‘H gene segment cannot join directly with a 1;; segment in heavy chain gene rearrangement. (10 pts) / \l D J Tris l5 due in the l‘m Hui, ‘51:, VH 35M; has a hoe tum sequence attached £0 /"\£ 0M 50 one; '4ch JH gene In orJa {Br Joinlng fa Law, {he #10 am gimme, \/ Can onlfi 'Jom Wk a jam; that has a Ham safari/Md Ali/add, 57m; JH 02"“: his A 2"hu“ azuw/ 74% W! 3015 :annr-é (Wad Joyce/(7.1% MM \ 10ml 'w'irl a DH 45m}. 761's Is A wuq #0 {531(3de \IKDHJH iain'mq, U . v ‘ \J VI. Circle the % BEST answer or fill in the blank (2 pts each). 1. Short gene segments found in between the VH and J H gene segments are referred to as the a. memory segments b. specificity segments @ diversity segments d. self/non-self segment 2. The following property renders a substance immunogenic. a. high molecular weight b. chemical complexity c. foreignness d. all of the above © all of the above are essential but not individually sufficient 3. In adaptive immunity, haptens do not a) require carrier molecules in order to be immunogenic b) react with specific antibodies when carriers are not employed. Q stimulate antibody responses without carriers d) react with specific antibodies when carries are employed. e) all of the above. f) none of the above 4. Which of the following would not bind to antigen? a) Fab (3) Fc C) F(ab’)2 d) Whole IgG 5. Whig of the following has no V domains Pc b) H chain C) F(ab')2 d) Fab e) a and d 6. Which of the following will bind to Fc receptors 3) Fab b) F(8b')2 c) Fc d) Whole IgG e) a and b 3} c and d ‘9) 7. The immunoglobulin class produced first in an immune response is a) IgG b) IgA c) IgE © W e) IgD 8. The major antibody class found in mucosal secretion is IgA. but also found as minor component is a) IgG b) IgE Cc) IgM d) IgD c) all of the above 9-10. The classes of antibody found on mature, but na‘t‘ve, B cells are IS M and o 11. Which class of immunoglobulin has subclasses in both humans and mice? 12. An immunologic adjuvant is a substance that a) I educes the toxicity of the immunogen. Enhances the immunogenicity of the immunogen. c) Enhances immunologic cross-reactivity. d) Enhances hematopoiesis. @Enhances the immune response against the immunogen. 13. Which of the classtes) of immunoglobulin below has four constant domains and no hinge region? a) IgG ® IgM c) IgA d) IgD e) c and d 14. Which class of immunoglobulin is most abundant in the sera? 1:8) IgG 17. A gene defect resulting in a deficiency in $5 leads to the most severe clinical manifestations. 18. A regulator of complement which acts on the classical and lectin pathways, but not the alternative pathway is 5:3 3; g . a 4 I3 10 19. Which of the following is true? a) The T cell uses the same set of V,D, and I gene segments as the B cell but uses different C gene segments. b) The TCR is bivalent and has two antigen binding sites. c) Mechanisms for the generation of diversity of T cell receptors are identical to those used by immunoglobulins. @ The Ig-a/Ig-B heterodimer and CD3 serve analogous functions in the B-cell receptor and T-cell receptor. 20. A protein complex associated with the TCR in the membrane and the major signal transduc ion component on T cells is the a CD3 b) CD4 c) CD28 d) CD40 e) CD64 21. Which of the following is not a property of the T—cell receptor? a) Exhibits MHC restriction b) 15 associated with CD3 @Exists in membrane-bound and secreted forms d) Contains domains with the Ig-fold structure 22 In generating T cell diversity, TCR genes do not use a) P-region nucleotide addition b. N—region nucle0tide addition is somatic mutation d) junctional flexibility 23. A molecule which stabilizes the MHC class 11 protein before it has acquired an antigenic peptide is a) tapasin b) calnexin © invariant chain d) TAP e) proteasome /J Lin 24. Proteins present in the RER membrane which transport peptides into the lumen of the RER where they bind class I MHC are the a) tapasin b) calnexin c) invariant chain @ TAP 1 and 2 e) proteasome 25. Interactions between antigen and antibodies involve all of the following except a) ionic bonds b) hydopohobic forces % covalent bonds van der Waals forces e) a very close fit between and epitope and the antibody 26. A patient is admitted with multiple bacterial infections and is found to have a complete abSence of C3. Which complement-mediated function would remain intact in such a patient? a) lysis of bacteria b opsonization of bacteria G5 generation of anaphylatoxins d) all of the above (9' none of the above 27. The alternative pathway of complement activation is characterized by the functions listed below, except a) activation of complement components beyond C3 in the cascade. b) participation of properdin. 0) generation of anaphylatoxin. @ use of C4. 28. The following activates the altemative pathway of complement a) lipopolysacchardies. b) some viruses and virus-infected cells. c) fungal and yeast cell walls (Zymosan) d) many strains of gram-positive bacteria @ all of the above 29. Which complement components could be missing and still leave the remainder of the complement system capable of activation by the alternative pathway. a) C1, C2. and C3 b) C3 only c) C2, C3, and C4 :1) C1, C2, and C4 @c1, c2 and c; 30. For Witation to occur both antigen and antibody must be multivalent. True False ...
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BMB 440 Exam II F'09 - EXAM2 5 BMB 440 Introductory...

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