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Lec2PP - Infuenza epidemics and pandemics 400 years 20...

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1 Bio1222 Lecture 2: Influenza Bio1222 H1N1: What’s in a name Hemagglutinin Neuraminidase Ribonucleoprotein (RNP) Lipid membrane
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2 Bio1222 Virus replication mRNA mRNA Bio1222 Antiviral drug therapy
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3 Bio1222 Tamiflu – mode of action Bio1222 Is a virus a form of life?
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4 Bio1222 Virus Life Cycle mRNA mRNA Bio1222 Influenza Genome
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5 Bio1222 Influenza Genome Bio1222 Influenza Genome Replication A U C C G G U A A A U A G G C C A U U U A U C C G G U A A A Viral RNA Chromosome
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6 Bio1222 Influenza Hosts Different strains usually infect different hosts: such as humans, swine or fowl. Cross-species transmissions to humans are common but are rarely transmitted to other people. (H1N1 swine flu is an exception.) Bio1222 Genetic Reassortment
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7 Bio1222
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Unformatted text preview: Infuenza epidemics and pandemics 400+ years, 20+ pandemics… why is fu still a problem? Bio1222 Reducing the impact • antiviral drugs • active immunity – exposure to antigen ! speciFc antibodies and memory cells – vaccines 8 Bio1222 Genetic variation in H1N1 •Why so much? Bio1222 Variation + selective pressure = ? • Selection on NA • Selection on HA 9 Bio1222 Evolution by natural selection… • depends on genetic variation • can be predictable (emergence of drug resistant strains) or unpredictable (antigen evolution) • humans may be the world’s greatest selective force...
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