Lec42 - Lec42EukaryoticGeneExpression BBiology 1222 io022...

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Bio022 Biology 1222 Haffie 09/10 Lec 42 Eukaryotic Gene Expression
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Bio022 Biology 1222 Haffie 09/10 Before next lecture . . . Review this lecture as needed. See mutation material in Chapter 14
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Bio022 Biology 1222 Haffie 09/10 Cytoplasm Nucleus Chromatin Pre-mRNA DNA Determines which genes are translated Mature RNAs Mature RNAs Determines types and availability of mRNAs to ribosomes Initiation of protein synthesis Ribosome Determines rate at which proteins are made New poly- peptide chains Finished proteins Protein breakdown Determines availability of finished proteins Transcriptional regulation Post - Transcriptional regulation Translational regulation Post- Translational regulation
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Biology 1222 Haffie 09/10 Metabolic Poisons… Metabolic Poisons… Amanitin made by a bio chemical pathway, no amanitin gene It inhibits RNA polymerase, Eukaryotic, it distryoys your liver and kidneys, and die eventually, not much can be done for it Diphtheria toxin Produced by bacteria A single molecule of this can kill a cell. It is a protein And some proteins are enzyme. IT is an enzyme and shuts down translation. One molecule therefore can kill a cell Degrates elongation factor for translation, translation shuts down, and the cells die. Their antibiotics, are made to kill eukaryotes,
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This note was uploaded on 04/12/2011 for the course BIO 1222 taught by Professor Maxwell during the Spring '08 term at UWO.

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Lec42 - Lec42EukaryoticGeneExpression BBiology 1222 io022...

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