Lec45 - Lec45CancerGenetics BBiology 1222 io022 Haffie...

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Bio022 Biology 1222 Haffie 09/10 Lec 45 Cancer Genetics
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Bio022 Biology 1222 Haffie 09/10 “The War on Cancer” - 1971 Many carcinogens are mutagens Viruses can be carcinogenic Cells are “programmed” to die
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Bio022 Biology 1222 Haffie 09/10 Ames Test Bacterial screen for chemical  mutagens Test strains are mutant (his - ) Reverse mutation  (“reversion”) caused by  chemical agent allows growth  on minimal medium lacking  histidine. mutagen
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Bio022 Biology 1222 Haffie 09/10 Retrovirus HIV inserts into chromosomes Get into your DNA unlike most viruses- that’s what makes them mutagenic- any element that inserts into the DNA, causing a mutation. They are also carsinogenic- cause cancer Retrovirus, are RNA, which are reverse transcribe into double stranded DNA
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Biology 1222 Haffie 09/10 DNA Viruses Herpes, smallpox,  mononucleosis, warts etc.  enter the nucleus but do not  (usually) integrate into  chromosomes. Don’t integrate into the DNA, 
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Lec45 - Lec45CancerGenetics BBiology 1222 io022 Haffie...

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