P lipid metabolism 2 - Lipid Metabolism. Part II. Learning...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
Lipid Metabolism. Part II. Transport of fatty acids in the mitochondrion Oxidation of fatty acids β -Oxidation Ketone bodies Biosynthesis of fatty acids Learning Objectives
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Oxidation of Fatty Acids Triacylglycerols, which are stored in adipocytes, are mobilized by hormone-sensitive lipase. Free fatty acids are released to the bloodstream, where they bind to a simple water-soluble protein albumin . Before being oxidized, fatty acids are activated in the cytosol by combining with CoA: Fatty acid + CoA + ATP Fatty acyl-CoA + AMP +PP i Example: fatty acid CH 3 -(CH 2 ) 14 -COO - fatty acyl-CoA CH 3 -(CH 2 ) 14 -C(O)-SCoA
Background image of page 2
Fig. 20-11 Carnitine : (CH 3 ) 3 N + -CH 2 -CH(OH)-CH 2 -COO - Transport of Fatty Acids into the Mitochondrion
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fig. 20-12 β -Oxidation A sequence of four reactions in the mitochondrial matrix cuts off two-carbon units. Fatty acyl-CoA: CH 3 -(CH 2 ) n -C β H 2 -C α H 2 -C(O)-S-CoA The process is called β -oxidation because the cleavage takes place at β - carbon, which becomes the carboxyl carbon at the next round.
Background image of page 4
β -Oxidation Oxidation of acetyl-CoA in the citric acid
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 17

P lipid metabolism 2 - Lipid Metabolism. Part II. Learning...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online