U Nucleotide Metabolism

U Nucleotide Metabolism - Nucleotide Metabolism...

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Unformatted text preview: Nucleotide Metabolism DNA-specific metabolites Synthesis of ribonucleotides Synthesis of thymine Cancer chemotherapy Nucleotide degradation Learning Objectives Nitrogenous Bases Bases are structural derivatives of either purine or pyrimidine Nucleotides are composed of a nitrogenous base linked to a sugar to which a phosphate group is attached. purine pyrimidine N N H N N N N Base, Nucleoside, and Nucleotide NH 2 NH 2 O 1 3 4 2 H H OH H OH H 2- O 3 P-O-CH 2 5 N NH 2 O 1 3 4 2 H H OH H OH H CH 3 5 Base Nucleoside Nucleotide N N H N N Adenine Adenosine Adenosine monophosphate N N N N N N N Functions of Nucleotides Almost all sells can synthesize nucleotides de novo.- coenzymes: FAD, NAD, CoA Nucleotides are components of :- high-energy compounds, e.g. ATP, Adenosine triphosphate GTP, Guanosine triphosphate UTP, Uridine triphosphate CTP, Cytidine triphosphate- nucleic acids Nucleotides do not provide significant amount of metabolic energy. Synthesis of Ribonucleotides O O H H OH H OH H 2- O 3 P-O-CH 2 N N N HN AMP and GMP are synthesized from inosine monophosphate (IMP). Inosine monophosphate, a precursor of AMP and GMP Before being incorporated into nucleic acids, nucleoside monophosphates are converted to nucleoside triphosphates....
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This note was uploaded on 04/10/2011 for the course SCIENCE 2EE3 taught by Professor Zhorov during the Spring '11 term at McMaster University.

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U Nucleotide Metabolism - Nucleotide Metabolism...

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