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U Nucleotide Metabolism - Nucleotide Metabolism Learning...

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Nucleotide Metabolism DNA-specific metabolites Synthesis of ribonucleotides Synthesis of thymine Cancer chemotherapy Nucleotide degradation Learning Objectives
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Nitrogenous Bases Bases are structural derivatives of either purine or pyrimidine Nucleotides are composed of a nitrogenous base linked to a sugar to which a phosphate group is attached. purine pyrimidine N N H N N N N
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Base, Nucleoside, and Nucleotide NH 2 NH 2 O H H OH H OH H 2- O 3 P-O-CH 2 N NH 2 O H H OH H OH H CH 3 Base Nucleoside Nucleotide N N H N N Adenine Adenosine Adenosine monophosphate N N N N N N N
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Functions of Nucleotides Almost all sells can synthesize nucleotides de novo. - coenzymes: FAD, NAD, CoA Nucleotides are components of : - high-energy compounds, e.g. ATP, Adenosine triphosphate GTP, Guanosine triphosphate UTP, Uridine triphosphate CTP, Cytidine triphosphate - nucleic acids Nucleotides do not provide significant amount of metabolic energy.
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Synthesis of Ribonucleotides O O H H OH H OH H 2- O 3 P-O-CH 2 N N N HN AMP and GMP are synthesized from inosine monophosphate (IMP). Inosine monophosphate, a precursor of AMP and GMP Before being incorporated into nucleic acids, nucleoside monophosphates are converted to nucleoside triphosphates.
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