I Glycogen - Glycogen Metabolism and Gluconeogenesis...

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lycogen Metabolism and Gluconeogenesis Glycogen Metabolism and Gluconeogenesis earning Objectives • Glycogen structure Learning Objectives • Glycogen breakdown • Enzymes catalyzing glycogen breakdown • Glycogen synthesis •S ynthesis of glucose
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lucose Storage and Synthesis Glucose Storage and Synthesis • Brain, red blood cells and some other tissues depend almost entirely on glucose as the source of energy • Glycogen is the stockpile of glucose for later metabolic use • A constant concentration of glucose in blood (~ 5 mM) provided by glycogen mobilization is provided by glycogen mobilization
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lucose Storage and Synthesis Glucose Storage and Synthesis obilization of glucose from glycogen occurs Mobilization of glucose from glycogen occurs primarily in the liver • After the meal, glucose is plentiful. Glycogen is synthesized • Liver glycogen can supply brain and erythrocytes with glucose for ~ 12 hours • Under fasting conditions, glucose is synthesized from oncarbohydrate precursors (e g amino acids) noncarbohydrate precursors (e.g., amino acids) gluconeogenesis
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verview of Glucose Metabolism Overview of Glucose Metabolism Fig. 16-1 G6P is produced by: - phosphorylation of free glucose - glycogen degradation gy g g - gluconeogenesis
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The Structure of Glycogen Fig. 16-2a
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This note was uploaded on 04/10/2011 for the course SCIENCE 2EE3 taught by Professor Zhorov during the Spring '11 term at McMaster University.

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I Glycogen - Glycogen Metabolism and Gluconeogenesis...

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