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K Citric acid cycle 2 - Citric Acid Cycle Part II Citric...

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Citric Acid Cycle Part II Citric Acid Cycle. Part II Learning Objectives • Eight reactions and eight enzymes of the citric acid cycle • Regulation of the citric acid cycle •ATP energy equivalent released in glucose catabolism • Regulation of the citric acid cycle • Metabolic reactions related to the citric acid cycle
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1. Citrate Synthase • Catalyzes the condensation of Acetyl- C A d l t t CoA and oxaloacetate • The initial reaction of the citric acid cycle • Carbon atoms from carbohydrates, fatty acids, and amino acids enter the cycle in COO - COO - H 2 O the form of acetyl group attached to CoA. C=O CH 2 HO-C-COO - CH 2 CH 2 + CH 3 -C(O)-S-CoA HS-CoA COO - COO - Oxaloacetate Citrate Acetyl-CoA Δ G 0' -32 kJ/mol
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