M Oxidative Phosphorylation

M Oxidative Phosphorylation - Oxidative Phosphorylation...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
xidative Phosphorylation Oxidative Phosphorylation earning Objectives Learning Objectives • Enzyme complexes in the electron transport chain • Structure of ATP synthase • Chemiosmotic theory
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
lectron Transport in Mitochondria Electron Transport in Mitochondria NADH NAD + Complex I 2e - Δ G 0' -70 kJ/mol Succinate FADH 2 2e - Complex II CoQ Fumarate Complex III ytochrome c Δ G 0' -37 kJ/mol Complex IV Cytochrome c Δ G 0' -112 kJ/mol 2H + +1/2 O 2 H 2 O 2e -
Background image of page 2
omple I: NADH oQ O idored ctase Complex I: NADH-CoQ Oxidoreductase Fig. 18-8 • Catalyses oxidation of NADH coupled to the reduction of CoQ: • The largest protein complex in the mitochondrial membrane. Contains 43 polypeptides. • Contains seven redox centers: FMN and 6 iron-sulfur clusters. • Electrons pass between the centers in the stepwise fashion.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
omplex I: NADH- oQ Oxidoreductase Complex I: NADH CoQ Oxidoreductase Fig. 18-8 • NADH donated two-electrons. Cytochrome c can accept only one electron. CoQ can transfer one or two electrons. • The electrons transfer between the 7 redox centers is coupled to pumping four protons out of the matrix. The detailed mechanism of proton pumping remains unknown.
Background image of page 4
Complex II: Succinate-CoQ xidoreductase • This complex contains succinate
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/10/2011 for the course SCIENCE 2EE3 taught by Professor Zhorov during the Spring '11 term at McMaster University.

Page1 / 17

M Oxidative Phosphorylation - Oxidative Phosphorylation...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online