MCB Midterm 2 - Organism Type Trypanosoma brucei (African...

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Organism Type Location Innate immune response Adaptive immune response Immune Evasion Transmission Pathogenesis Trypanosoma brucei (African Sleeping Sickness) Protozoan Extracellular (bloodstream) Macrophages Neutrophils Cytokines— inflammation (Il-1, Il-6, TNF-a) TH2 B cells Ab IgG For all protozoa: Extra: opson; ADCC Intra: neutr. Antigenic variation (VSG) In Chaga’s ( cruzi ), replicates in macrophages and muscle cells) Fly vector Travels through lymphatics and blood stream Leishmania Protozoan Intracellular (macrophages) Macrophages Neutrophils inflammation Th1 CTL Macrophages IFN-gamma (TH2 pathway causes more disease due to overactive inflamm) In the endosome of macrophage Fly vector Infects macrophages and lives in endosome Plasmodium Protozoan Intracellular (hepatocytes liver) RBCs Macrophages Neutrophils inflammation Liver cells TH1 CTLs (MHC I) Macrophages RBCs Ab IgG TH2 (mesozoites) VAR ags express different antigens and different traits but our
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MCB Midterm 2 - Organism Type Trypanosoma brucei (African...

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