BIO2A03-2011-L16 - Lecture 16 Kidney III Fig 19-8 podocyte...

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Unformatted text preview: Lecture 16 Kidney III Fig 19-8 podocyte Foot processes fenestration Glomerulus membrane (filtration barrier) Endothelial cell Basement membrane Epithelial cell (podocyte) Slit pore (between podocytes) Renal corpuscle Filtration slit Glomerular capillary Bowmans Capsule Filtration Barrier at M.W ~ 68,000 podocyte slit pores basement membrane matrix - negative charge repels proteins endothelial fenestrae Filtration Barrier 1. Glomerular Filtration NFP =( P GC + BC ) ( P BC + GC ) (60mmHg +0mmHg) (15mmHg + 29mmHg) + 16 mmHg- = = Starling -Landis Forces involved in glomerular filtration Fig 19-9 Recall P CAP = 38mmHg for a systemic capillary N T+1 P GC P BC GC BC Constrict aff. arteriole? = increase aff. Resistance = decrease net filtr. pressure = decreases GFR Constrict eff. arteriole? = increase eff. Resistance = I ncrease net filtr. pressure = increase GFR Balance of aff. and eff. resistances is very important in controlling GFR Level of MAP is also very important in controlling GFR Afferent arteriole Efferent arteriole P GC 3. Tubular Secr etion3....
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BIO2A03-2011-L16 - Lecture 16 Kidney III Fig 19-8 podocyte...

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