BIO2A03-2011-L17 - BIO 2A03 Lecture 17 Renal IV 1 C h a ng...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
BIO 2A03 Lecture 17 Renal IV 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
C ha ng e s  in G FR c a n b e  us e d to  re g ula te  wa te r lo C o ntro l o f G FR b y c o ns tric tio n a nd va s o dila tio
Background image of page 2
Analysis of Renal Function Exc re tio n Ra te  = E x  = [X] u  x UFR • Clearance Rate  = C x = the rate (ml/min) at which plasma is “totally  cleared” of a substance by the kidney         C x  = [X]   u  x UFR                         [X] p If X is a substance which is totally cleared from the plasma (e.g.  PAH), then clearance rate is total renal plasma flow rate –  e.g. C PAH = 450 ug/ml x 2 ml/min  = 900 ml/min   1ug/ml Excretion Rate Conc in plasma Amt of plasma that would contain 450ug of PAH Clinical determination 3
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Clearance of PAH =[X]u * UFR / [X]p = (1250mmole/L * 2.0 ml/min) / 4mmole/L 4
Background image of page 4
Analysis of Renal Function If X is a substance which is freely filtered at the glomerulus (like  virtually everything else in plasma), but neither secreted nor reabsorbed then its clearance rate is the   glomerular filtration rate   (GFR) - e.g.  inulin C inulin  = GFR= 90 ug/ml x 2 ml/min  = 180 ml/min            1ug/ml GFR is 20% of renal plasma flow (20% of 900ml/min is 180ml/min) Filtration rate of x   =    [X] p  x GFR                     5
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Analysis of Renal Function • CR
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 17

BIO2A03-2011-L17 - BIO 2A03 Lecture 17 Renal IV 1 C h a ng...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online