BIO2A03-2011-L18 - !"#$%&'($ )*+,-.*$/0$...

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)*+,-.* /0 1*234 +52,6 7*-.5 "
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Na + Reabsorption and its Regulation by Aldosterone - Aldosterone is a released from the adrenal cortex in response to NaCl in ECF. Na + /K + ATPase K + Na + K + K + Na + Na + [Na + ] [Na + ] [Na + ] [K + ] [K + ] [K + ] - Na + reabsorption is coupled to K + secretion Aldosterone Receptor Regulation of NaCl and H 2 O by the Kidney % 89: /;</= steroid hormone
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Na + Reabsorption – Summary of Aldosterone Action 1. Aldosterone diffuses across basolateral membrane and binds to a receptor in principal cells. 2. Receptor activation leads to: a) of Na + and K + channels in apical membrane. b) of more Na + and K + channels for insertion into membrane. c) synthesis of more Na + /K + ATPases for insertion into membrane. RESULT: Increased permeability of DT/CCD to Na + , Increased NaCl reabsorption and K + secretion. Regulation of NaCl and H 2 O by the Kidney ( cytoplasmic opening synthesis apical basolateral
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Regulation of NaCl and H 2 O by the Kidney Interactions between ADH and Aldosterone -Since H 2 O and Na
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BIO2A03-2011-L18 - !&quot;#$%&amp;'($ )*+,-.*$/0$...

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