BIO2A03-2011-L18 - BIO 2A03 Lecture 18 Click to edit Master...

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Click to edit Master subtitle style 4/13/11 BIO 2A03 Lecture 18 Renal cont… Neuro I
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Na+ Reabsorption and its Regulation by Aldosterone - Aldosterone is a steroid hormone released from the adrenal cortex in response to low NaCl in ECF. Na+/K+ATPase K+ Na+ K+ K+ Na+ Na+ [Na+] [Na+] [Na+] [K+] [K+] [K+] - Na+ reabsorption is coupled to K+ secretion Aldosterone Receptor Regulation of NaCl and H2O by the Kidney 22 Fig 19- 14
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4/13/11 Na+ Reabsorption – Summary of Aldosterone Action 1. Aldosterone diffuses across basolateral membrane and binds to a cytoplasmic receptor in principal cells. 2. Receptor activation leads to: a) opening of Na+ and K+ channels in apical membrane. b) synthesis of more Na+ and K+ channels for insertion into apical membrane. c) synthesis of more Na+/K+ ATPases for insertion into basolateral membrane. RESULT: Increased permeability of DT/CCD to Na+, Increased NaCl reabsorption and K+ secretion. Regulation of NaCl and H2O by the Kidney 33
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4/13/11 Regulation of NaCl and H2O by the Kidney Interactions between ADH and Aldosterone
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BIO2A03-2011-L18 - BIO 2A03 Lecture 18 Click to edit Master...

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