BIO2A03-2011-L25 - 031611

BIO2A03-2011-L25 - 031611 - Biology 2A03 - 2011 Lecture 25...

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Biology 2A03 - 2011 Lecture 25 Respiration III
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Spirometry
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Tidal Volume = amount of air breathed in and out on a single breath ~ 0.5L Inspir. Res. = max. amount that can be inhaled above normal inhalation ~ 3L Expir. Res .= max. amount exhaled beyond normal exhalation ~ 1.5L Resid. Vol. = amount left inside, cannot be exhaled even with max. effort ~ 1L Insp. Capacity = tidal volume + insp. reserve ~ 3.5L Functional Residual Capacity = exp. reserve + residual volume ~ 2.5L Vital Capacity = exhale maximally, then quantify max inhalation ~ 5.0L Total Lung Capacity = measured after maximal inhalation , ~ 6.0L Spirometer record
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Minute Ventilation = total air flow into (and out of) the respiratory system per minute Minute Ventilation = total volume x breathing rate e.g. 6750 ml/min = 450 ml x 15/min Minute Ventilation = Alveolar Ventilation ? NO This difference is because of Anatomic Dead Space which is air “stuck” in the conducting zone (does not participate in gas exchange) Alveolor Ventilation (V A ): V A = [Tidal Volume – Anat. Dead Space] x Breathing Rate 4500 ml/min = [ 450 ml - 150 ml ] x 15/min
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Anatomical Dead Space
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300 ml of “new” air is entering the 2500 ml functional residual capacity which contains “old” air Dilution Factor = 300 ml new + 2500 ml old = 9.3 x 300 ml new ==> Only ~10% replacement of alveolar air per breath at rest
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BIO2A03-2011-L25 - 031611 - Biology 2A03 - 2011 Lecture 25...

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