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BIO2A03-2011-L25 - Biology2A032011 Lecture25 RespirationIII...

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Biology 2A03 - 2011 Lecture 25 Respiration III
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Spirometry
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Tidal Volume amount of air breathed in and out on a single breath ~ 0.5 L Inspir. Res. max. amount that can be inhaled above normal inhalation ~ 3 L Expir. Res .= max amount that can be exhaled beyond normal exhalation~ 1.5 Resid. Vol. = amount left inside, cannot be exhaled even with max. effort ~ 1 L  Insp. Capacity = tidal volume + insp. reserve ~ 3.5 L Functional Residual Capacity = exp. reserve + residual volume ~ 2.5 L Vital Capacity = exhale maximally, then quantify max inhalation ~ 5.0 L Total Lung Capacity = measured after  maximal inhalation , ~ 6.0 L  Spirometer record
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Minute Ventilation   = total air flow into (and out of) the respiratory system per  minute Minute Ventilation = Tidal Volume x Breathing Rate e.g.  6750 ml/min =  450 mL  x  15/min Minute Ventilation = Alveolar Ventilation ? This difference is because of  Anatomical Dead Space  which is air “stuck” in the  conducting zone (does not participate in gas exchange) Alveolor Ventilation  (V A ): V = [Tidal volume – Anat. Dead Space] x Breathing Rate 4500 ml/min = [ 450 mL – 150 mL ]       x    15/min no
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Anatomical   Dead Space
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300 ml of “new” air is entering the  2500 ml of  functional residual capacity which contains “old” air Dilution Factor =  300 ml new + 2500 ml old = 9.3 x                                          300 ml new ==> Only ~  10%
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