BIO2A03-2011-L27 - Biology 2A03 - 2011 Lecture 27...

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Biology 2A03 - 2011 Lecture 27 Respiration V
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pH 7.6 pH 7.4 pH 7.2 Temp = 39ºC  P50 Unloading point during exercise Unloading point at rest Loading point at rest
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Loading point at rest Unloading point at rest Unloading point during exercise pH 7.6 pH 7.4 pH 7.2 Temp = 39ºC  Loading point  during exercise During exercise, O unloading can be  increased to 90% (i.e. venous reserve  decreased to 10%) by combined effect of  Pv O2 , P CO2 , pHv, &  temperature.
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Organic Phosphate m o le c ule s  a re  a ls o  im po rtant ne g a tive   a llo s te ric  m o difie rs  o f O 2  b inding , b ut pla y little  ro le  during   e xe rc is e Ma m m a ls   - 2,3-dipho s pho g lyc e ra te  (2,3-DPG ) Birds  -  IP 5  (ino s ito l pe nta pho s pha te )  -  Inc re a s e  in RBC  [ pho s pha te ] s hifts  c urve  to   rig ht  in m o s t  m a m m a ls  during   a na e m ia , hig h a ltitude , re s pira to ry dis e a s e s .   This  he lps  im pro ve  O 2   unlo a ding  to  the  s ys te m ic  tis s ue s Ho we ve r s o m e  m a m m a lia n s pe c ie s  whic h a re  na tive  to  hig h 
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This note was uploaded on 04/12/2011 for the course BIOL 2A03 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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BIO2A03-2011-L27 - Biology 2A03 - 2011 Lecture 27...

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