BIO2A03-2011-L29 - Biology 2A03 Lecture 29 - 2011 Acid base...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Biology 2A03 Lecture 29 - 2011 Acid base endocrinology (H. Smith (1954) - a most useful monument to human laziness) pH = pK + log [anion of an acid] = 4.0 + log [HCO 3- ] [acid] [H 2 CO 3 ] However: [H 2 CO 3 ] <===> Dissolved [CO 2 ] = Pa CO2 x aCO 2 c.a. ======> The Henderson-Hasselbalch Equation pHa = pK + log [HCO 3- ] = ~ 6.1 + log [HCO 3- ] Diss. [CO 2 ] Pa CO2 x aCO 2 Regulated by metabolism and kidney - slow ~ constant Regulated by breathing - fast ~ constant ~ constant pHa = ~ 6.1 + log [HCO 3- ] Pa CO2 x aCO 2 pHa = ~ 6.1 + log 20 = 7.4 pHa is regulated at 7.4 by keeping [HCO 3- ] at 20 Pa CO2 x aCO 2 * Respiratory acidosis- is too high (therefore pHa too low) due to hypo- ventilation . -If its a chronic effect, kidney slowly compensates by accumulating (excreting H + ). Respiratory alkalosis- Pa CO2 is too low (therefore pHa too high) due to hyper-ventilation . -If its a chronic effect, kidney slowly compensates by excreting HCO 3- (accumulating H + )....
View Full Document

Page1 / 10

BIO2A03-2011-L29 - Biology 2A03 Lecture 29 - 2011 Acid base...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online