BIO2A03-2011-L30-template

BIO2A03-2011-L30-template - B iology 2A03 2011 L ect ur e...

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Biology 2A03 - 2011 Lecture 30 Endocrinology
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Table 5-5 Functionally, the 3 hormone classes based on chemical origin break down into two groups: A. Peptides, Proteins , Serotonin & Catecholamines B. Steroids & Thyroid Hormones A B *(but endocytosis may occur) * Metabolic breakdown & rapid ( < 1 h) slow (hours - days) excretion
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Effects on Target Cells : 1. Direct - activate or inhibit some function of the cell. 2. Indirect = permissive effects - alter the sensitivity of the target cell to other hormones by up-regulating or down- regulating their receptors Controls on Hormone Secretion : 1 . Changes in plasma [ nutrients ] or [ ions ] - e.g. [ glucose ] on insulin & glucagon; [Ca 2+ ] on calcitonin & parathyroid hormone 2. Another hormone (or self-inhibition) - e.g. hypothalamic releasing/ inhibiting hormones on anterior pituitary hormones 3 . Neural controls - direct from CNS (hypothalamic hormones) or via the autonomic nervous system
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Direct CNS Control Via Autonomic N.S. Portal system
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Hypothalamus -Pituitary Complex: - “master endocrine gland(s)” - “ neuro-endocrine interface Posterior Pituitary - neural tissue “neurohypophysis Hypothalamus - neural tissue Axons terminate in the posterior pituitary Release of neurohormones PVN
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BIO2A03-2011-L30-template - B iology 2A03 2011 L ect ur e...

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