3HH3 module 1 lecture 1-post

3HH3 module 1 lecture 1-post - The Cytoskeleton Bio 3HH3...

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Bio 3HH3 2010 1 The Cytoskeleton
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Bio 3HH3 2010 2 Readings Alberts et al. (5th ed.) Chapter 16: The cytoskeleton You may find the same information in Lodish et al. (5th ed.) book Biomembranes and cell architecture (Ch. 5, section 4) Microtubules (Ch. 20)
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Bio 3HH3 2010 3 Cytoplasm is highly organized The organization depends on the cytoskeleton Cytoskeleton plays crucial role in the development and functioning of eukaryotic cells. Examples include - Generating contractile force in muscle cells Elongation of nerve axons Control of cell division during mitosis Control of cell movement Movement of intracellular components (e.g., separation of chromosomes,
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Bio 3HH3 2010 4 Cytoskeleton is a cytoplasmic system of filaments/fibers. Cytoskeleton consists of three types of fibers Actin filaments (AFs) or Microfilaments (MFs) Microtubules (MTs) Intermediate filaments (IFs) Fibers have been grouped based upon their diameter, type of subunits, and subunit arrangements. Accessory proteins modify the dynamics and structure of AFs and MTs.
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Bio 3HH3 2010 5 Each type of cytoplasmic filament is constructed from smaller protein subunits Actin filaments (or microfilaments) are made up of monomeric actins . Microtubules are made up of dimeric subunits of α - and β -tubulin . Intermediate filaments are assembled from large and diverse family of proteins (e.g., lamins ) Cytoplasmic filaments are polymers
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Bio 3HH3 2010 6 Filament structure
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Bio 3HH3 2010 7 Actin filaments Structure 5-9 nm diameter made of globular actin subunits (G-actin) found in most animal cells, also higher plants “Microfilament” and “actin (or F-actin) filament” are synonyms. “F-actin” is often used for those formed in vitro.
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This note was uploaded on 04/12/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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3HH3 module 1 lecture 1-post - The Cytoskeleton Bio 3HH3...

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