3HH3 module 2 lecture 5-Myosin-post

3HH3 module 2 lecture 5-Myosin-post - Molecular motors...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
Molecular motors Types of motor proteins that move along cytoskeleton AF-based: Myosins MT-based: Kinesins and Dyneins IF-based: None! Myosins move along AFs MTs Readings in Alberts: Chapter 16: The cytoskeleton Molecular motors, åPages 1010-1025
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Molecular motor proteins differ in: The type of polarized Flament with which they associate The direction of movement along the Flament The types of cellular cargo transported by these molecular motors include: vesicles, organelles (mitochondria, lysosomes, chloroplasts), chromosomes, other cytoskeletal Flaments But all are similar in: Structure The conversion of chemical energy stored in ATP into mechanical energy that is used to move cellular cargo attached to motor
Background image of page 2
Basic structure of motors Lodish et al., 3-23 The head domains bind to a cytoskeletal fber (AFs or MTs) and the tail domain attaches to a cargo. ATP hydrolysis provides energy ±or “walking”.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Motor proteins move unidirectionally along their cytoskeletal track in a stepwise manner from one binding site to the next As they move along, they undergo a series of conformational changes (a mechanical cycle)
Background image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/12/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

Page1 / 20

3HH3 module 2 lecture 5-Myosin-post - Molecular motors...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online