3HH3 module 2 lecture 5-Myosin-post

3HH3 module 2 lecture 5-Myosin-post - Molecular motors...

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Molecular motors Types of motor proteins that move along cytoskeleton AF-based: Myosins MT-based: Kinesins and Dyneins IF-based: None! Myosins move along AFs MTs Readings in Alberts: Chapter 16: The cytoskeleton Molecular motors, åPages 1010-
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Molecular motor proteins differ in: The type of polarized filament with which they associate The direction of movement along the filament The types of cellular cargo transported by these molecular motors include: vesicles, organelles (mitochondria, lysosomes, chloroplasts), chromosomes, other cytoskeletal filaments But all are similar in: Structure The conversion of chemical energy stored in ATP into mechanical energy that is used to move cellular cargo attached to motor
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Basic structure of motors Lodish et al., 3-23 The he a d dom a ins bind to a cytoske le ta l fibe r (AFs or MTs) a nd the ta il dom a in a tta che s to a ca rgo. ATP hydrolysis provide s e ne rgy for “wa lking”.
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Motor prote ins m ove unidire ctiona lly a long the ir cytoske le ta l tra ck in a ste pwise m a nne r from one binding site to the ne xt As the y m ove a long, the y unde rgo a se rie s of conform a tiona l cha nge s (a m e cha nica l cycle )
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This note was uploaded on 04/12/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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3HH3 module 2 lecture 5-Myosin-post - Molecular motors...

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