3HH3 module 2 lecture 6-post

3HH3 module 2 lecture 6-post - Microtubules: Motors There...

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Microtubules: Motors Most are plus- end directed, but not all! Minus-end directed. There are two types of motor proteins that move along microtubules of the cell: Kinesin family Dynein family Alberts, 3 rd 3ed
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Kinesins A tetramer made of two identical heavy chains and two identical light chains A pair of globular heads generates force by hydrolyzing ATP and binding MT (N termini, motor domain) Kinesins move vesicles/organelles towards the plus end of MT e.g. from cell body to synaptic knobs Kinesinlike proteins (KLPs) Motor domain position determines function Tails vary since they haul different cargoes
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Kinesins and Kinesin-related proteins: Does not move; catastrophin Minus-end directed MT sliding Monomer; plus-end directed Dimer; plus- end directed
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Functions Vesicle transport: http://www.youtube.com/watch? http://www.hhmi.org/news/ popups/gustafson2_pop.htm l
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The force-generating domains of myosin and kinesin are similar: nucleotide-binding pocket and ATP-hydrolysis Also similar to G protein super family (GTPases)
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This note was uploaded on 04/12/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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3HH3 module 2 lecture 6-post - Microtubules: Motors There...

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