3HH3 module 2 lecture 6-supplement

3HH3 module 2 lecture 6-supplement - conformations. Both...

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Power stroke of dynein: (Monomeric dynein in Fagella) http://www.fbs.leeds.ac.uk/staff/profile.php?tag=Burgess Nucleotide-free dynein and ADP- dynein is attached to the MT. ATP bound form is released.
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Burgess et al, 2003. Dynein structure and power stroke. ATP and vanadate (Vi), dynein forms a stable complex (ADP²Vidynein), thought to mimic the ADP-Pi state and hence the prepower-stroke conformation of the motor Its structure in the .absence of nucleotide (apo-dynein) is thought to represent the post-power-stroke conformation Electron microscope studies of the outer-arm dynein complex in situ have shown that these two biochemical states have distinct
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Unformatted text preview: conformations. Both are present in the chemicomechanical cycle seen in the presence of ATP Movies of dynein power stroke: http://www.nature.com/nature/journal/v421/n6924/suppinfo/ nature01377.html Movie 1: averages after classiFcation of the stalk. When exed (pointing left) the stalk is gently curved (clockwise from tip to base). When extended (pointing up) the stalk is straight. https://reck-peterson.med.harvard.edu/publications/Reck-Peterson_2006.pdf Movies: http://www.cell.com/supplemental/S0092-8674(06)00862-2 Model for movement is different than that of kinesin: Alternating ShufFe:...
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This note was uploaded on 04/12/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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3HH3 module 2 lecture 6-supplement - conformations. Both...

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