3HH3 module 2 lecture 7-post

3HH3 module 2 lecture 7-post - Slide 1 Cell division: Role...

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Unformatted text preview: Slide 1 Cell division: Role of cytoskeletal machines The M phase consists of two major processes, Nuclear division (mitosis) Cell division (cytokinesis) Readings (MBoC book) 5th ed. Ch 16 (1034-1035) Slide 2 Both these pr ocesses ar e per for med by cytoskeletal machinar y. Slide 3 Tubulin is reorganized to assemble the mitotic spindle: Spindle assembly: http://valelab.ucsf.edu/images/movies/fig4.mov Spindle elongation (anaphase): http://valelab.ucsf.edu/images/movies/fig4a.anaphase_ http://valelab.ucsf.edu/research/recentresearch/mitosisandmotors/mitosisandkine sin.html Mitotic spindle is composed of MTs and MT-dependent motor proteins Slide 4 Microtubule-dependent motor proteins play crucial role in the assembly and function of mitotic spindle. The balance between (+)-end and (-)-end motor proteins is critical. The three classes of MTs that are involved in this process Slide 5 I nterphase: MT are long and stable Mitosis: MT are shorter and more dynamic A balance between MAPs and catastrophins creates...
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This note was uploaded on 04/12/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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3HH3 module 2 lecture 7-post - Slide 1 Cell division: Role...

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