3HH3 module 3 lecture 8-post

3HH3 module 3 lecture 8-post - Cilia and fagella A...

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Slide 1 Cilia and fagella A specialized arrangement of microtubules in eukaryotes Locomotor appendages that protrude from some cells Readings (Alberts, MboC) Pages 1031-1034 (5th ed.) Functions: Movement of unicellular eukaryotes and germ cells Extensions of cells that form part of a tissue layer may move Fuid over the surface of the tissue.
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Slide 2 What are the differences? Cilia Large numbers on the surface of a cell 0.25 um in diameter, 2-20 um in length Force is generated perpendicular to the axis of the cilia Strokes that work like oars Flagella One (or two) per cell 0.25 um in diameter, 10-200 um in length Undulating motion, force in same direction as axis of the ±agella
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Slide 3 Cilia move fuid across the surFace oF a group oF cells in a tissue In the human body, huge number oF cilia ( > 10 9 /cm 2 ) line the respiratory tract, sweeping layers oF mucus, trapped particles oF dust and bacteria out to the mouth
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Slide 4 Cilia of ciliated columnar cells Goblet cells and nuclei of ciliated columnar cells lamina propria Cross-section of human trachea (epithelium) Movie: http://users.umassmed.edu/michael.sanderson/mjslab/Cilia_Page.htm
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Slide 5 Many epithelial surfaces in the body are ciliated, containing cells with tiny hair-like structures beating in synchrony to move secretions or objects. ciliated epithelia in the vesicles of the brain which circulate the cerebrospinal Fuid oviduct which move the ova from the ovary to the uterus. respiratory tract, ciliated epithelial cells sweep clean dust and germs trapped in mucus secreted by "goblet cells" in the epithelium.
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Slide 6 Flagella: Undulating motion Can propel single cells through fuid e.g., protozoan (Paramecium) and sperm cells Movie: http://www.youtube.com/watch?v=oija6n5kTHk&feature=related
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Slide 7 Movies: http://www.youtube.com/watch?v=6d5GlkLIsD8 http://www.chlamy.org/companion.html Two fagella oF Chlamydomonas. M. Polin, I. Tuval, K. Drescher, J.P. Gollub, and R.E. Goldstein, Science 325, 487 (2009).
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Slide 8 Sperm Sperm Chlamydomonas MCB, Lodish, Fig. 20-27 Undulating movement of Fagella on a single cell allow the cell to move through a liquid medium.
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Slide 9 What are the similarities? Common ultrastructure. The axoneme is the cytoskeletal structure underlying both the cilia and the fagella. Core oF microtubules sheathed in an extension oF the plasma membrane (axoneme) Apical Basal
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MCB, Lodish, Fig.20-25 Nine doublets of microtubules arranged in a ring and two single microtubules in the center (9+2 pattern) Flexible “wheels” of proteins connect the outer doublets to each other and to the center microtubules Motor molecules (dynein arms) associate neighboring doublets
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This note was uploaded on 04/12/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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3HH3 module 3 lecture 8-post - Cilia and fagella A...

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