3HH3 module 3 lecture 9-post

3HH3 module 3 lecture 9-post - Cell crawling The crawling...

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Cell crawling The crawling movements of cells across a surface represent a basic form of cell locomotion: seen in a wide variety of different kinds of cells movements of amoebas the migration of embryonic cells during development the invasion of tissues by white blood cells to Fght infectio the migration of cells involved in wound healing the spread of cancer cells during the metastasis the extension of nerve cell processes phagocytosis Movie: http://www.youtube.com/watch?v=vAaQ4WS8QhI
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Single cell amoeba: Developing axons: Macrophages and neutrophils Metastatic cancer cells:
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http://www.bristol.ac.uk/biochemistry/research/goc.html Migrating cells often polarize forming a broad protruding edge in the direction of travel (seen here on the right), and a narrow, contractile tail (the left). Red = Actin Green = cytoskeletal regulatory protein, WAVE2 How do regulatory proteins control co-ordinated changes in the shape of the cytoskeleton and cell movement?
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Cell Crawling: The Cycle Protrusion Attachment Retraction
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Protrusion Extension of membrane structures that is largely powered by actin polymerization. Filopodia are one-dimensional projections Examples include migrating growth cones and some types of Fbroblasts Actin Flaments are organized into long parallel bundles Lamellipodia are two-dimensional projections Examples include epithelial cells and Fbroblasts Actin Flaments are organized in a branching “dendritic” network Pseudopodia are three-dimensional projections Examples, amoebae and neutrophils
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Filopodia Lamellipodia Pseudopodia
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An actin network underlies protrusion formation Actin network in the lamellipodia and Flopodia. Plus ends of actin are at the forefront of the lamellipodia. http://www.imba.oeaw.ac.at/research/vic-small/research/ MBoC FIg.16.87
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Dynamics oF actin treadmilling can drive protrusion growth. Assembly
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This note was uploaded on 04/12/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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3HH3 module 3 lecture 9-post - Cell crawling The crawling...

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