3HH3 module 5 lecture 12-post

3HH3 module 5 lecture 12-post - Asymmetry in C. elegans...

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Slide 1 Asymmetry in C. elegans embryo. Asymmetry originates from the sperm entry point which defines the posterior pole of the egg. Symmetric egg Fertilization Asymmetric embryo
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Slide 2
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Slide 3 First division:
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Slide 4 vie: first division /celldynamics.org/celldynamics/courses/archive/2003gndcb/wormweb/intro.html
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Slide 5 anterior posterior What difference do you see between the two cells? Size. Posterior cell is smaller. What you can’t see is that the distribution of proteins between the two cells is also very different. AB P1
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Slide 6 http://www.nature.com/nrm/journal/v6 /n10/fig_tab/nrm1738_F2.html The consequence of the difference is that each daughter gives rise to a different set of differentiated cell types.
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7 P4 … germline Generation of founder cells in the early embryo. Anterior is to the left, posterior to the right, dorsal is up and ventral down. The germ-line precursors (P cells) are shown outlined with blue. Each of the founder cells generated by asymmetric division are indicated with a different color. The founder cells each display a characteristic cell cycle rate and lineage: The AB lineage produces hypodermis, neurons, anterior pharynx and other cell types; MS produces the somatic gonad, muscle, the majority of the pharynx, neurons and gland cells; E produces all intestine; C produces muscle, hypodermis and neurons; D produces muscle; P4 is the germ-line precursor. The 16-cell embryo shown in (E) is simplified and does not show the daughters of the 4th AB cell division, which occurs at approximately the same time as the P3 division. http://www.wormbook.org/chapters/www_asymcelldiv/asym
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This note was uploaded on 04/13/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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3HH3 module 5 lecture 12-post - Asymmetry in C. elegans...

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