3HH3 module 5 lecture 13-post

3HH3 module 5 lecture 13-post - Par genes are required for...

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Slide 1 Par genes are required for first asymmetric division: Nomarski Micrographs of Two-Cell EmbryosNomarski micrographs of two-cell embryos from wild-type mothers (A) and mothers of genotypes par-1 (B), par-2 (C), par-3 (D) and par-4 (E). Taken from Kemphues et al. (1988).
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Slide 2 6 Par genes identified: (Kemphues) Most of these genes were required for two related aspects of cell polarization: Might encode the mechanism for cell polarization in the one- cell stage C. elegans embryo … 1) the asymmetric positioning of the mitotic spindle leading to asymmetric cell division 2) the asymmetric positioning of a set of proteins and RNAs that are important for cell fate specificication
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Slide 3 Core polarity determining genes: These interact with one another in functional complexes and are highly conserved.
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Slide 4 Some Mechanisms That Localize PAR Proteins and Specific Downstream Proteins at the One- Cell Stage in C. elegans (Top) Sperm entry to right (posterior) (Bottom) The mitotic spindle adopts an asymmetric position. Black lines indicate genetic interactions; short gray lines indicate biochemical interactions. Proteins indicated in gray are not localized to just one side of the embryo. Par-4 and Par-5 remain symmetrically localized.
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Slide 5 PAR Localization in Multiple Systems: PAR-3, PAR-6, PKC, CDC42, or some or all of these in combination are enriched at the places indicated with orange lines, and PAR-1 is enriched at the places indicated with blue lines.
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This note was uploaded on 04/13/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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3HH3 module 5 lecture 13-post - Par genes are required for...

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