3HH3 module 5 lecture 14-post

3HH3 module 5 lecture 14-post - Polarization is established...

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Slide 1 http://skoplab.weebly.com/research.html Polarization is established under the control of the Rho GTPase RHO-1 and is maintained by the Rho GTPase CDC-42.
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Slide 2 CDC42: universal pattern among eukaryotes 1) the creation of a landmark 2) followed by the organization of the polarity machinery 3) attachment to cytoskeletal elements that exert pulling forces on structures such as the mitotic spindle This protein was first identified in budding yeast for its role in orienting the mitotic spindle during cell division. We saw it earlier for its role in the movement of the leading edge during cell motility.
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Slide 3 What is the role of Cdc-42? Gottaa, M. M.C. Abrahama and J.Ahringer. 2001. CDC-42 controls early cell polarity and spindle orientation in C. elegans. Current Biology. 11( 7): 482-488 Acetoa, D. M. Beersa and K. Kemphues. 2006. Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans. Developmental Biology. 299(2): 386-397
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4 Asymmetric localization of PAR-6 and PAR-2 is lost in cdc-42(RNAi) embryos. Gottaa et al, 2001.
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This note was uploaded on 04/13/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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3HH3 module 5 lecture 14-post - Polarization is established...

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