3HH3 module 6 Lecture16-post

3HH3 module 6 Lecture16-post - CellSignaling

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Slide 1 Living cells continuously monitor their surroundings  Multicellular organisms are evolved with elaborate cell  communication mechanisms  Cells must be able to communicate with one another in  order to control their own behavior for the benefit of the  organism as a whole Cells use signal molecules  to communicate with others Cell Signaling Alberts et al., 5th ed., Ch. 15
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Slide 2 Cells have developed sophisticated intracellular machinery to  receive  and interpret  signals This requires activities of various proteins that interact with each  other and form signaling networks Examples of cell signaling include control of cytoskeleton assembly/cell morphology cell death (apoptosis) cell proliferation/cell cycle cell fate specification during development
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Slide 3 Restricted response to specific signals Cells are often  programmed to  respond to specific  signals that lead to  activation of  distinct signaling  pathway.
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Slide 4 Cell signaling pathway: 
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Slide 5 Enzyme-linked Proteolysis-mediated RTK signaling Overview of Signaling Pathways
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Slide 6 Receptor Diversity: Ion-channel-linked receptors Involved in synaptic signaling between electrically excitable cells Multipass transmembrane proteins  Signaling is mediated by neurotransmitters that transiently open/close  an ion channel G-protein-linked receptors GTP-binding protein (G-protein) mediate the interaction between the  receptor and another membrane-bound protein (enzyme or ion channel) 
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3HH3 module 6 Lecture16-post - CellSignaling

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