3HH3 module 6 Lecture17 Dm eye-post

3HH3 module 6 Lecture17 Dm eye-post - Development of the...

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Unformatted text preview: Development of the Drosophila eye: Determining the first cell: R8 Notch signaling and lateral inhibition Drosophila development: 3rd larval stage. Imaginal discs in Drosophila: How drosophila appendages develop http://www.nature.com/nrm/jo urnal/v2/n2/fig_tab/nrm0201_ 089a_F1.html Drosophila eye: each eye consists of 750-800 light- sensing units (ommatidia) containing eight photosensitive neurons (photoreceptors): R1 through R8 Comparison of head and eye-antennal imaginal disc morphology in Drosophila and the stalk-eyed fly S. beccarii. Teleopsis dalmanni. http://scienceblogs.com/pharyngula/2007/03/the _lovely_stalkeyed_fly.php Eye development: requires the organized selection and differentiation of a patterned array of R8 photoreceptors – the founding photoreceptor of each ommatidium that coordinates the incorporation of all other photoreceptors. R8 development is a complex process that requires the integration of transcription factors and signaling pathways, many of which are highly conserved and perform similar functions in other species. Eye imaginal disc: Morphogenic Furrow (MF) moves posterior to anterior (right to left). Dynamic Atonal expression (green) within the morphogenetic furrow. Photoreceptors are recruited progressively – ommatidia close to the MF are immature and consist of fewer photoreceptors than do ommatidia located more posteriorly. The first photoreceptor to differentiate with passage of the MF is R8: which then coordinates recruitment of all subsequent photoreceptors. Step1: Selection of R8...
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This note was uploaded on 04/13/2011 for the course BIOL 3HH3 taught by Professor Mccelland&dej during the Winter '11 term at McMaster University.

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3HH3 module 6 Lecture17 Dm eye-post - Development of the...

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