3HH3 module 6 Lecture18 post

3HH3 module 6 Lecture18 post -...

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Slide 1 Progressive differentiation of photoreceptors:  The role of RTKs in R7 specification http://8e.devbio.com/article.php?ch=6&id=272
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Slide 2 The recruitment and differentiation of cell types of each  ommatidium starts at the posterior edge of the morphogenetic  furrow and follows a highly stereotypic temporal sequence. 1) R8 is the first cell to differentiate 2) R2/R5 and R3/R4 are added in pairs 3) R1/R6 are next 4) and finally R7 is recruited. Addition of the nonneuronal cone and  pigment cells completes development.
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Slide 3 Differentiation of the different cell types in each ommatidium is  controlled by at least two receptor tyrosine kinases (RTKs): Drosophila EGF receptor (DER): most cells in eye Sevenless (SEV): only required for specification of the R7  photoreceptor
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Slide 4 Receptor tyrosine kinase (RTK)  signaling pathway:
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Slide 5 Sevenless (SEV):  A tangential section through a  wild-type eye reveals six large  rhabdomeres in each ommatidium  corresponding to photoreceptors R1  to R6 and the centrally located  small rhabdomere of the R7  photoreceptor cell (E).  The rhabdomere of the R8 cell is  not visible in this apical section and  is located below the R7  rhabdomere. In  sev  mutant flies (B), only the R7  cell is missing, indicated by the lack  of the central small rhabdomere. Raabe, 2000.
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Slide 6 A similar phenotype is  observed for a loss of  function mutation in  Bride of Sevenless  (Boss)  which codes for  the ligand of the RTK  receptor,  Sevenless  (Sev)
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3HH3 module 6 Lecture18 post -...

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