3HH3 module 6 Lecture20wg-post

3HH3 module 6 Lecture20wg-post - WNTSignaling:Drosophilawing

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Slide 1 Wingless adult fly: Wingless expression in the  larval wing precursor: Ligand: WNT Receptor: Frizzled WNT Signaling: Drosophila wing
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Slide 2 Frizzled = seven-pass  transmembrane receptor LRP = low-density  phospholipid receptor protein  receptor; acts as a co-receptor Dishevelled = scaffold protein  (adaptor) β -catenin = cell-cell adhesion  protein that interacts with  cadherin; unstable unless  associated with cadherin
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Slide 3 β -Catenin acts here in as a signal  transduction protein. Degradation of catenin: Complex =  casein kinase 1 (CK1) glycogen synthase kinase 3 (GSK3) axin = scaffold protein Adenomatous polyopsis coli (APC) =  scaffold protein Phosphorylation of  catenin targets it for  ubiquitinylation and  degradation.
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Slide 4 Wnt binding brings together  two receptors, Frizzled and  LRP. Recruitment of components of  the degradation complex free        β -catenin (Armadillo). β -catenin can now translocate  to the nucleus and activate  transcription.
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Slide 5 Switch from transcriptional inactivation to activation Inhibitory complex Activating complex  Groucho   β -catenin  Lef1/TCF  Lef1/TCF Target genes include c-Myc which  induces cell growth and division.
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Slide 6 dMyc: a Drosophila mutation (known as  diminutive ), resulting in  an abnormally small body size and female sterility, is due to a  hypomorphic mutation in  dmyc . myc
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3HH3 module 6 Lecture20wg-post - WNTSignaling:Drosophilawing

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