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Unformatted text preview: Prions are Pro teinaceous in fectious agents which cause neurodegenerative disorders that afflict mammals. These infectious agents are the cause of bovine spongiform encephalopathy (also known as Mad Cow Disease), as well as human diseases such as CJD, Gerstamann-Stausller-Schienker syndrome, and fatal familial insomnia. They are different diseases, but everything finally ends in neurodegeration and finally death. As we mentioned before, these diseases are the result of a conformational transition in the normal cellular prion protein to the diseased isoform which is PrPsc. Firrstly, Scrapie This disease is occurred in sheeps. So, in scrapie, the prion attacks the CNS of the organism and results in damaging plaques and holes in the brain tissue. Cuts and scrapes in the skin can result in entery for the protein and travel to the immune cells. But It is still unkown how scrapie is transmitted from sheep to sheep. The disease can be genetically passed down but symptoms appear later on in life. Symptoms include loosing wool, disease can be genetically passed down but symptoms appear later on in life....
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- Three '11