nucleophilic

nucleophilic - N ucleophilic Aromatic Substitution Michelle...

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Nucleophilic Aromatic Substitution Michelle Hamilton INTRODUCTION Aromatic rings normally undergo electrophilic substitution due to high pi- electron density. The previous experiment was an electrophilc reaction, however aromatic rings will undergo nucleophilic substitution, SnAr, if a good leaving group such as a halogen is ortho and/or para to electron-withdrawing group. The electron withdrawing group deactivates the ring toward electrophilic substitution, but activates it toward nucleophilic substitution. TABLE OF REAGENTS MF MW Mass Density volume BP 1-bromo-2-4 dinitrobenze ne C H BrN O 247g/mol 0.296g Aniline C H N 93.13g/mo l 0.450 1.0217g/mo l .46 184°C Ethanol C H O 46.07g/m ol 0.789g/mol 5.0 78.4°C
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Nucleophilic Aromatic Substitution Michelle Hamilton PROCEDURES 1. Place 0.296g of 1-bromo-2-4-dinitrobenzene, 0.44mL aniline, 5mL ethanol and a magnetic stir bar in a Glass Chem microwave reaction vessel. 2.
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nucleophilic - N ucleophilic Aromatic Substitution Michelle...

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