synopsis 2 - E ndocrinology BIOL 4631.01 M ichelle Hamil...

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Endocrinology BIOL 4631.01 Michelle Hamilton Long-term maintenance of the anabolic effects of GH on the skeleton in successfully treated patients with acromegaly Acromegaly is a chronic metabolic disorder in which there is too much growth hormone and the body tissues gradually enlarge. Acromegaly occurs in about 6 of every 100,000 adults. It is caused by abnormal production of growth hormone after the skeleton and other organs finish growing. The cause of the increased growth hormone release is usually a noncancerous (benign) tumor of the pituitary gland. The pituitary gland, which is located just below the brain, controls the production and release of several different hormones, including growth hormone. Development of symptoms in acromegaly is often slow and gradual. It may be so gradual that symptoms go unnoticed for years or even decades. •Untreated, acromegaly is linked to early heart disease, high blood pressure, heart rhythm disorders, diabetes, and colonic polyps, a precursor of colon cancer.
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