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edit_distance - University of North Texas Biocomputing...

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University of North Texas Biocomputing 1 Biocomputing University of North Texas Dynamic Programming: Edit Distance Source: www.bioalgorithms.info University of North Texas Biocomputing DNA Sequence Comparison: First Success Story Finding sequence similarities with genes of known function is a common approach to infer a newly sequenced gene’s function In 1984 Russell Doolittle and colleagues found similarities between cancer-causing gene and normal growth factor (PDGF) gene University of North Texas Biocomputing Cystic Fibrosis Cystic fibrosis (CF) is a chronic and frequently fatal genetic disease of the body's mucus glands (abnormally high level of mucus in glands). CF primarily affects the respiratory systems in children. Mucus is a slimy material that coats many epithelial surfaces and is secreted into fluids such as saliva University of North Texas Biocomputing Cystic Fibrosis: Mutation Analysis If a high % of cystic fibrosis (CF) patients have a certain mutation in the gene and the normal patients don’t, then that could be an indicator of a mutation that is related to CF A certain mutation was found in 70% of CF patients, convincing evidence that it is a predominant genetic diagnostics marker for CF University of North Texas Biocomputing Cystic Fibrosis and CFTR Gene : CFTR (Cystic Fibrosis Transmembrane conductance Regulator) University of North Texas Biocomputing Mechanism of Cystic Fibrosis The CFTR protein (1480 amino acids) regulates a chloride ion channel Adjusts the “wateriness” of fluids secreted by the cell Those with cystic fibrosis are missing one single amino acid in their CFTR Mucus ends up being too thick, affecting many organs
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