University of North TexasBiocomputing1BiocomputingUniversity of North TexasDynamic Programming:Edit DistanceSource: www.bioalgorithms.infoUniversity of North TexasBiocomputingDNA Sequence Comparison: First Success Story •Finding sequence similarities with genes of known function is a common approach to infer a newly sequenced gene’s function•In 1984 Russell Doolittle and colleagues found similarities between cancer-causing gene and normal growth factor (PDGF) geneUniversity of North TexasBiocomputingCystic Fibrosis •Cystic fibrosis(CF) is a chronic and frequently fatal genetic disease of the body's mucus glands (abnormally high level of mucus in glands). CF primarily affects the respiratory systems in children. •Mucus is a slimy material that coats many epithelial surfaces and is secreted into fluids such as saliva University of North TexasBiocomputingCystic Fibrosis: Mutation AnalysisIf a high % of cystic fibrosis (CF) patients have a certain mutation in the gene and the normal patients don’t, then that could be an indicator of a mutation that is related to CFA certain mutation was found in 70% of CF patients, convincing evidence that it is a predominant genetic diagnostics marker for CFUniversity of North TexasBiocomputingCystic Fibrosis and CFTR Gene : CFTR (Cystic Fibrosis Transmembrane conductance Regulator)University of North TexasBiocomputingMechanism of Cystic Fibrosis•The CFTR protein(1480 amino acids) regulates a chloride ion channel•Adjusts the “wateriness” of fluids secreted by the cell•Those with cystic fibrosis are missing onesingle amino acid in their CFTR•Mucus ends up being too thick, affecting many organs
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