Exam III, Sp '02 MB text

Exam III, Sp '02 MB text - properties of eukaryotic...

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BIOL/BIOC 4570/5340 Biochem. and Mol. Biol. of the Gene Exam III, Spring 2002 Exam Scoring Record your answers in the spaces provided. If you require more space for any of the essay 1. _______/25 questions, use the back of the page on which the question is printed. Read each question 2. _______/20 carefully. The essay questions often have multiple parts. Make sure you have answered 3. _______/25 each of them so that you will not lose points due to simple omission. The maximum points 4. _______/15 possible on this exam is 105 (including 5 bonus points) 5. _______/20 _________/105 Total Points 1. DNA repair. a. What is the particularly mutagenic product produced when an alkylating agent (methylating agents in this case) reacts with guanine in DNA? Why is this mutagenic? Provide diagrams. b. Describe/diagram two mechanisms by which this lesion may be repaired in human cells (provide all necessary enzymes and cofactors). 2. (20 pts) Describe/diagram/explain two possible explanations for epigenic inheritance patterns based upon observed or hypothesized
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Unformatted text preview: properties of eukaryotic chromatin. 3. (25 points) Eukaryotic Chromatin a. What is the basic building block of chromatin structure? What are its constituents? Draw and label one. b. Show by diagram and description how these basic units are further condensed to the level of a metaphase chromosome. c. What was the experimental evidence which supported the initial data obtained from electron microscopy and suggested the presently accepted theory concerning the above described basic repetitive unit of chromatin structure? Briefly describe/diagram the experimental protocols with an example of anticipated results. 4. (15 pts) What is the structure/organization/function of telomeric DNA sequences? How are these sequences lost and replaced (diagram the enzyme and the mechanism used). 5. (20 pts) Diagram/explain the current model for how recombination between homologous duplexes occurs in E. coli....
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This note was uploaded on 04/15/2011 for the course BIOL 1733 taught by Professor Staff during the Spring '08 term at North Texas.

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