Lecture 19 - Lecture 19 T Cells-Cells The Cellular Immune...

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Lecture 19: T Cells:-Cells The Cellular Immune Response I) Cell Types a. Cytotoxic T-cells(Tc): Recognize cells with “wrong” surface components (e.g. virus-infected or “cancerous cells” and lyses them b. Helper T cells (Th): bind antigen presenting cells activates B&T cells c. Surpressor T-cells: prevent immune system from attacking some antigens II) Mechanism a. T Cell Receptor: cell surface receptor looks like antibody but only 2 chains alpha and beta (variable and constant regions differ) with transmembrane domains bind antigen presenting by another cell activates the T-cell b. Major histocompatibility complex (MHC)- class of membrane glycoproteins that help target T-cells i. Class I MHCs 1. On all nucleated cells 2. Bind peptides(~10-20aa’s) produced by the cells (broken down proteins inside the cell & transported to the surface) 3. Recognized by Cytotoxic T Cells via T cell receptor and CD-8 on Tc ii. Class II MHCs 1. On the antigen presenting cells (e.g. B cells, macrophages, dendritic cells) 2.
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