Final Notes on Fatty Acid Synthesis

Final Notes on Fatty Acid Synthesis - 1) Alpha-amino acid +

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Regulation of Fatty Acid Synthesis: Synthesis Cytoplasm ACP-SH NADPH 3C + 2C 4C + 1C (malonyl-ACP) Regulators: Citrate Breakdown Mitochondria CoASH NAD+, FAD 4C 2C + 2C (acetyl-CoA) Regulators: Insulin Biosynthesis of Triacylglycerols (storage of fatty acids) 1) Pathway is on pg. 820
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Ketone Synthesis/Breakdown a) Synthesis: a. Things to know: Ketone formation (in liver) to regenerate CoA for B oxidation without the need of acetyl-CoA through TCA cycle. In addition, this process increases greatly during starvation and diabetes mellitus. Brain adapts to ketone in times of starvation as opposed to glucose
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Oxidative Phosphorylation (why does reduction potential vary for FADH2) look at notes B 1) ETC 2) Proton-motive force 3) Blocking of ATP or electron flow 4) Uncouplers etc. . thermogenin 5) Radicals are formed from Q complex and undergoes –(superoxide dismutase) H2O2 –(glutathione peroxidase) H2O Amino Acid Oxidation(look at notes C) pg. 683
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Unformatted text preview: 1) Alpha-amino acid + alpha-ketoglutarate (amino transferase/PLP) alpha-keto acid + glutamate 2) Glutamate (glutamate dehydrogenase) alpha keto-glutarate + NH4 + NADH2 a. Note: rxn 1 is in cytosol of liver and rxn 2 is in mitochondria of liver b. Look at problem set for ch18. For transamination problem 3) Transport via 2 methods: a. Glutamate gives NH4 to pyruvate alanine b. Glutamate is given NH4 w/ glutamine synthetase glutamine 4) Know which 20 amino acids are ketogenic/glucogenic 5) Know the inborn diseases done for quiz 7 -_- all of them 6) Know the whole Urea Cycle GET THE BIG PICTURE Note: Overall rate of amino acid oxidation is regulated by energy needs of cell @ glutamate dehydrogenase (inhibited by GTP, activated by ADP allosterically)? Gluconeogenesis/Glycogen Synthesis: 1) 4f of study guide???? WTH? Cholesterol Biosynthesis/ Diabetes and Metabolism (Guest lectures) Random...
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Final Notes on Fatty Acid Synthesis - 1) Alpha-amino acid +

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