Chapter20 - 11/16/09 Antibiotics Chapter 20 Substances...

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11/16/09 1 Chapter 20 Antimicrobial Drugs Antibiotics Substances produced by microorganisms that inhibit growth of other microorganisms Technically, term does not include man-made chemicals such as sulfonamides “Antimicrobial drugs” is a more inclusive term Discovery of Penicillin Alexander Fleming, 1928 Penicillium notatum mold contaminated his Petri plate “Chance favors only the prepared mind” (Pasteur) Bacterial colonies didn’t grow near the mold Mold produces an antibiotic Fig. 1.5 Development of Penicillin Clinical trials in 1940 by other scientists Started a new era of medicine “Miracle” for treatment of wound infection in WWII Today death by infectious disease is 5% of the level in 1900
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11/16/09 2 Spectrum of Activity Some drugs affect fewer types of microbes (narrow spectrum) and some affect more types (broad spectrum) Penicillin is a narrow spectrum antibiotic; it only affects Gram-positive cells Broad spectrum antibiotics, such as tetracycline, affect Gram-negative and Gram-positive
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This note was uploaded on 04/18/2011 for the course MICR 130 taught by Professor Umemoto during the Fall '09 term at University of Hawaii, Manoa.

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Chapter20 - 11/16/09 Antibiotics Chapter 20 Substances...

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