104Lecture5

104Lecture5 - Lecture 5 4/14/11 Background reading: MBOC...

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Lecture 5 4/14/11 Background reading: MBOC 5 th Edition: Chapter 12: pages 695-704; 723-736 MBOC 4 th Edition: Chapter 12: pages 659 - 669; 689 - 702 Outline: Targeting of proteins to intracellular destinations Transmembrane transport In vitro Translocation Signals Signal hypothesis Components of transport mechanism Signal recognition particle (SRP) SRP receptor Translocator Signal peptidase Transmembrane proteins
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Targeting of proteins to intracellular destinations Targeting of Proteins to intracellular destinations Problem: Average eukaryotic cell synthesizes 1,000 – 10,000 different proteins. Most are synthesized in the cytosol. How do they get to their correct destinations in the cell? Proteins destined for nucleus, mitochondria, peroxisomes, plastids and ER must transit across membrane. Implies distinct set of traffic controls
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Transmembrane Transport Transit of Proteins to Endoplasmic Reticulum (ER) All proteins destined for the ER, Golgi, early and late endosomes, secretory vesicles, lysosomes, plasma membrane, cell surface and for secretion must enter the ER.
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Endoplasmic reticulum
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Lumen
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This note was uploaded on 04/17/2011 for the course BIS 104 taught by Professor Scholey during the Winter '08 term at UC Davis.

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104Lecture5 - Lecture 5 4/14/11 Background reading: MBOC...

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