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Unformatted text preview: proteins ability to bind B-catenin, so that B-catenin, so that B-catenin accumulates in the nucleus and stimulates the transcription of c-myc and Wnt target genes, this resulting uncontrolled cell proliferation promotes the development of cancer. 6) Based on the model 15-72, the Wnt genes have to be presented to activate transcription of DNA into mRNA and Groucho has to be inactivated by the unphosphorylation of B-catenin when they migrate and accumulate to the nucleus. 7) GSK-3B phosphorylates B-catenin marking the protein for ubiquitylation and rapid degradation in proteasomes. APC helps promote the degradation of B-catenin by increasing the affinity of the degradation complex of B-catenin, as required for effective phosphorylation of B-catenin by GSK-3B. Axin holds the protein complex together....
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This note was uploaded on 04/18/2011 for the course BIOLOGY 430 taught by Professor Dr.tenlen during the Fall '10 term at Fayetteville State University.
- Fall '10